Probiotics
Consuming a diet rich in healthful bacteria and supplementing with probiotic formulas can help support a healthy microbiota balance. Probiotic supplementation may be especially useful when environmental factors, genetics, medication, food sensitivity or high levels of stress or anxiety are present.
Modern Western diets often lack fresh fruits and vegetables as well as fermented foods like yogurt, kimchee, and sauerkraut that provide the body with beneficial bacteria. For example, the highly advantageous lactic acid bacterium, Lactobacillus plantarum, colonizes the gastrointestinal tracts of the majority of people in Africa and Asia consuming traditional diets rich in plant materials. In contrast, L. plantarum is found in fewer than 25% of Americans. Similar intestinal deficiencies of L. paracasei and L. rhamnosus in western populations have been described.
The human gastrointestinal(GI) tract is host to the most densely populated microbial ecosystem known. Comprising more than 400 identified species and at least another 400 species unknown except by ribosomal RNA sequences, this complex community is essential to normal human development and health. Healthy, balanced GI microbiota is central to the immune system, regulates against intestinal disturbances, supplies nutrients and vitamins, facilitates mineral absorption, and metabolizes cholesterol and bile salts.
Nova Rē’s Broad Spectrum Probiotic:
25 billion CFU per capsule
Healthful probiotic bacteria must survive the acidic passage through the stomach to the small intestine and colon. A high-CFU probiotic preparation helps ensure that adequate numbers of microorganisms survive to reach the distal small bowel and colon to exert their beneficial effects. Probiotics have been shown to be safe in numerous clinical trials and meta-analyses, even at very high doses. Nova Rē’s Broad Spectrum Probiotic capsules contain 25 billion colony forming units (CFU).
Hypoallergenic formula - Casein and gluten free
Probiotics used in our Broad Spectrum Probiotic are cultured on a proprietary vegetable-based growth media free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.
Inulin oligosaccharide base
Inulin is a non-digestible carbohydrate derived from chicory root. Inulin and other non-digestible carbohydrates, referred to as prebiotics, can be ingested by the healthful probiotics it contains, stimulating their growth. Nova Rē’s Broad Spectrum Probiotic contains inulin as a base ingredient in place of maltodextrin, commonly found in probiotic supplements. Inulin is a naturally derived ingredient that is generally well-tolerated by the highly sensitive person.
A versatile formula suitable for children or adults
Adults and children alike can benefit from our Broad Spectrum Probiotic through the replenishment of essential intestinal probiotic bacteria that may be depleted by the modern American diet, medication, or a health conditon. Nova Rē’s Broad Spectrum Probiotic provides intensive microbiota support, especially useful when health concerns or medications lead to diminished populations of these essential commensal organisms.
Acid stable matrix
Nova Rē’s Broad Spectrum Probiotic and Children’s Probiotic Formula utilize proprietary technology to protect the probiotics against stomach acid, to ensure that more viable healthful bacteria reach the small intestine and colon. A natural, vegetarian polysaccharide of marine origin that is mixed with the probiotics during production, on exposure to stomach acid, forms a gel-like matrix surrounding the probiotics, effectively shielding them from the acid environment.
Supporting essential intestinal microdiversity
Nova Rē’s probiotic quality assurance commitment consists of a thorough, independent testing program that monitors and ensures the identity, activity, and hypoallergenicity of our finished products.
Genetic identification by RNA ribotyping
Bacterial strains in Nova Rē’s probiotics have undergone rRNA ribotyping, a highly reproducible, precise diagnostic genetic fingerprint, to validate the specific genetic pattern in comparison to established, documented strains.
Free of all major allergens
Nova Rē probiotic species are cultured on growth media which are free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives. This has been, and continues to be verified by input.
GMP manufacturing
Nova Rē probiotics are manufactured and packaged at a state-of-the-art, GMP-compliant facility, where filtered air systems and a humidity- and temperature-controlled environment help ensure product stability and purity.
Independent laboratory analysis
All probiotic raw materials for every batch and each finished product undergo independent laboratory analysis for probiotic enumeration and other tests to ensure products meet or exceed the company’s specifications and GMP requirements.
Validated potency
Nova Rē probiotics are formulated with sufficient overages, stored under refrigerated conditions, and shipped with temperature-control packs to ensure that, when properly stored and refrigerated, they will retain their stated potency for at least one year from the date of manufacture.
How It Works
Broad Spectrum Probiotic Species Characteristics
Bifidobacterium species:
Bifidobacterium bifidum
Second most prominent species identified in breast-fed infants. The population of B. bifidum declines in the elderly.
Produces an extracellular β-galactosidase which degrades lactose.
Produces a suite of enzymes dedicated to the metabolism of human milk oligosaccharides (HMO).
Efficiently degrade mucin, beneficially influencing epithelial barrier and host responses.
High adhesion rate and competitive binding to gastric epithelial cells.
May affect regulation of NF-κB signaling pathways, supporting healthy epithelial cells.
May support recruitment of lymphocytes to the intestinal mucosa.
Bifidobacterium breve
One of the 3 Bifidobacterium species commonly found in the gut of neonates and breastfed infants.
Resistant to both bile and acid.
Facilitates its own colonization while reducing colonization of competing microbes.
Produces numerous enzymes that degrade or modify carbohydrates, including pullulan and amylopectin.
May beneficially modulate B-cell proliferation and IgA induction in intestinal cells.
May support healthy antibody response to an oral vaccine.
Administration of B. breve strains increased Actinobacteria and the ratio of Firmicutes/Bacteroidetes in the microbiota of children on a gluten-free diet.
Bifidobacterium lactis
Exceptionally hardy with unusual resistance to acid and high tolerance of oxygen.
Worldwide it is the most widely used Bifidobacterium probiotic.
Shown in experimental animals to support normal bowel movement frequency and stool consistency.
Excellent adherence to intestinal mucin, a prerequisite for competition with other bacteria.
May help modulate visceral sensitivity to stress.
In animals, supported healthy gastric permeability during NSAID use.
Produces endopeptidases that digest proteins rich in proline, such as casein and gliadin.
May support cellular immunity by modulating T cells, NK cells, and the phagocytic activities of monocytes and polymorphonucleocytes.
May help support a healthy plasma IgG response to vaccination.
Has beneficially modulated Bifidobacteria/enterobacteria balance in elderly individuals.
Bifidobacterium longum
Often the dominant Bifidobacterium species found in humans.
Exceedingly well-adapted to the colonic microenvironment, fermenting a broad spectrum of plant-derived complex carbohydrates and polyols.
Cross-feeds butyrate-producing species. Supports the growth of Lactobacillus, Enterococcus, Bifidobacterium, and Bacteroides/ Prevotella in fecal cultures.
May preserve cell integrity against the e ects of bacterial enterotoxins.
Plays a role in host defense mechanism and strengthen the epithelial barrier.
May play a role in modulating local inflammatory responses.
Lactobacillus species
Lactobacillus acidophilus
Widely recognized probiotic.
Commonly added to yogurt along with the starter cultures, and highly tolerant to gastric acid, bile salts, and proteases.
Hydrolyzes casein and gluten.
Ferments a variety of carbohydrates including fructooligosaccharides (FOS) and galactooligosaccharides (GOS).
Produces beneficial bacteriocins.
May support healthy cholesterol metabolism.
Lactobacillus casei
Hardy, adaptive transient species.
Produces proline-specific peptidases to assist breakdown of the prolinerich molecules casein and gluten.
Beneficially modulates IgAproducing cells, supporting innate immune responses to immunological challenges.
Supports a healthy balance between the Th1 and Th2 parts of the immune response.
Supports normal stool consistency and bowel movements in healthy individuals.
Lactobacillus plantarum
Nearly universally present in the intestinal microbiota of people consuming plant-based, Mediterranean diets; commonly found in vegetarians. Generally lacking in the gut microecology of people consuming a standard Western diet.
Effectively metabolizes oligofructans (i.e., FOS), semi-resistant carbohydrates found in vegetables.
Very hardy species. High survival under simulated gastric and intestinal conditions.
Able to assimilate cholesterol under various intestinal conditions.
May enhance intestinal barrier function.
Strongly attaches in vitro to human intestinal cells and can antagonize adherence of competing microbes.
May beneficially modulateinterleukins, natural killer (NK) cells, and cytokines.
May beneficially modulate T cells that participate in acquired cell-mediated immunity.
Lactobacillus paracasei
Transient bacterium that colonizes the intestines when regularly consumed in the diet.
Excellent acid-tolerance; highly resistant to pepsin and pancreatin.
Able to ferment inulin and phleins (plant fructans).
Produce beneficial bacteriocin-like substances and biosurfactants.
Homeostasis-restoring e ect in colonic mucosa.
Supported healthy structure of intestinal villi and colonic crypts, as well as healthy stooling patterns, in animals.
High lactic acid production may contribute to a healthy vaginal microbiota.
Lactobacillus rhamnosus
Transient microorganism that colonizes the intestines when regularly consumed.
Produces more peptidases than any other Lactobacillus.
Modulates Th1- and Th2-type immune response markers.
Supports healthy fecal butyrate levels.
Supports normal epithelial barrier permeability and morphology in vitro.
Supports intestinal epithelial homeostasis and modulation of cytokines in vitro.
Supports normal bowel function in children.
Lactobacillus salivarius
Homofermentative Lactobacillus metabolizes a variety of monoand disaccharides.
Enhances calcium uptake by intestinal-like cells in culture.
Supports intestinal barrier function in vitro.
Secretes a wide range of beneficial bacteriocins.
May beneficially modulate interleukin production and balance.
May work synergistically with B. breve to modulate interleukins.
Transient microorganisms
Lactobacillus bulgaricus
Subspecies of L. delbrueckii.
Highly adapted transient Lactobacillus closely related to L. acidophilus.
Supported systemic immune system, NK cell activity, and viral resistance in mice.
L. bulgaricus and S. thermophilus exhibit a symbiotic relationship in the production of beneficial exopolysaccharides (EPS).
Streptococcus thermophilus
Aerotolerant, anaerobic, grampositive coccus highly adapted to metabolizing lactose.
Genetically facilitates casein breakdown.
Produces organic acids that lower pH in culture and antagonize the growth of less desirable organisms.
Lactic acid production supported healthy bacterial balance in an animal model.
May support healthy bowel function in infants.